Molecular modeling of neurological membrane proteins - from binding sites to synapses.
Neurosci Lett
; 700: 38-49, 2019 05 01.
Article
en En
| MEDLINE
| ID: mdl-29802917
ABSTRACT
The field of molecular mechanics studies of proteins has developed enormously since its origin in the 1970's, and many applications and methodologies have branched from the original idea of the force field. The applications of such methodologies are far spread and commonplace in neuroscience research today. In this mini-review, we outline the main methodologies applied when studying events ranging from ligands binding within small binding sites, through overall large-scale conformational changes, to the even larger-scale oligomerization events of neurological membrane proteins. The limitations and caveats of the methods are discussed, while examples of recent applications are described and their implications discussed. We have chosen to focus on the monoamine transporters throughout, with a few examples from neurological membrane proteins such as ionotropic and metabotropic neurotransmitter receptors.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Modelos Moleculares
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Proteínas de la Membrana
Límite:
Animals
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Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article