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Protein disorder-order interplay to guide the growth of hierarchical mineralized structures.
Elsharkawy, Sherif; Al-Jawad, Maisoon; Pantano, Maria F; Tejeda-Montes, Esther; Mehta, Khushbu; Jamal, Hasan; Agarwal, Shweta; Shuturminska, Kseniya; Rice, Alistair; Tarakina, Nadezda V; Wilson, Rory M; Bushby, Andy J; Alonso, Matilde; Rodriguez-Cabello, Jose C; Barbieri, Ettore; Del Río Hernández, Armando; Stevens, Molly M; Pugno, Nicola M; Anderson, Paul; Mata, Alvaro.
  • Elsharkawy S; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Al-Jawad M; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Pantano MF; Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK.
  • Tejeda-Montes E; Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK.
  • Mehta K; Materials Research Institute, Queen Mary University of London, London, E1 4NS, UK.
  • Jamal H; Laboratory of Bio-Inspired and Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, 38123, Trento, Italy.
  • Agarwal S; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Shuturminska K; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Rice A; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Tarakina NV; Department of Materials, Imperial College London, London, SW7 2AZ, UK.
  • Wilson RM; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
  • Bushby AJ; Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
  • Alonso M; Institute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
  • Rodriguez-Cabello JC; Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK.
  • Barbieri E; Department of Materials, Imperial College London, London, SW7 2AZ, UK.
  • Del Río Hernández A; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Stevens MM; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Pugno NM; Materials Research Institute, Queen Mary University of London, London, E1 4NS, UK.
  • Anderson P; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
  • Mata A; Materials Research Institute, Queen Mary University of London, London, E1 4NS, UK.
Nat Commun ; 9(1): 2145, 2018 06 01.
Article en En | MEDLINE | ID: mdl-29858566
ABSTRACT
A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Calcificación Fisiológica / Elastina / Dentina / Proteínas Intrínsecamente Desordenadas / Minerales Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Calcificación Fisiológica / Elastina / Dentina / Proteínas Intrínsecamente Desordenadas / Minerales Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article