Protein disorder-order interplay to guide the growth of hierarchical mineralized structures.
Nat Commun
; 9(1): 2145, 2018 06 01.
Article
en En
| MEDLINE
| ID: mdl-29858566
ABSTRACT
A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder-order interplay using elastin-like recombinamers to program organic-inorganic interactions into hierarchically ordered mineralized structures. The materials comprise elongated apatite nanocrystals that are aligned and organized into microscopic prisms, which grow together into spherulite-like structures hundreds of micrometers in diameter that come together to fill macroscopic areas. The structures can be grown over large uneven surfaces and native tissues as acid-resistant membranes or coatings with tuneable hierarchy, stiffness, and hardness. Our study represents a potential strategy for complex materials design that may open opportunities for hard tissue repair and provide insights into the role of molecular disorder in human physiology and pathology.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Calcificación Fisiológica
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Elastina
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Dentina
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Proteínas Intrínsecamente Desordenadas
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Minerales
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article