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Sphingolipid biosynthesis in man and microbes.
Harrison, Peter J; Dunn, Teresa M; Campopiano, Dominic J.
  • Harrison PJ; School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK. Dominic.Campopiano@ed.ac.uk.
Nat Prod Rep ; 35(9): 921-954, 2018 09 19.
Article en En | MEDLINE | ID: mdl-29863195
ABSTRACT
A new review covering up to 2018 Sphingolipids are essential molecules that, despite their long history, are still stimulating interest today. The reasons for this are that, as well as playing structural roles within cell membranes, they have also been shown to perform a myriad of cell signalling functions vital to the correct function of eukaryotic and prokaryotic organisms. Indeed, sphingolipid disregulation that alters the tightly-controlled balance of these key lipids has been closely linked to a number of diseases such as diabetes, asthma and various neuropathologies. Sphingolipid biogenesis, metabolism and regulation is mediated by a large number of enzymes, proteins and second messengers. There appears to be a core pathway common to all sphingolipid-producing organisms but recent studies have begun to dissect out important, species-specific differences. Many of these have only recently been discovered and in most cases the molecular and biochemical details are only beginning to emerge. Where there is a direct link from classic biochemistry to clinical symptoms, a number a drug companies have undertaken a medicinal chemistry campaign to try to deliver a therapeutic intervention to alleviate a number of diseases. Where appropriate, we highlight targets where natural products have been exploited as useful tools. Taking all these aspects into account this review covers the structural, mechanistic and regulatory features of sphingolipid biosynthetic and metabolic enzymes.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Fosfotransferasas (Aceptor de Grupo Alcohol) / Oxidorreductasas de Alcohol / Aldehído-Liasas / Serina C-Palmitoiltransferasa Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esfingolípidos / Fosfotransferasas (Aceptor de Grupo Alcohol) / Oxidorreductasas de Alcohol / Aldehído-Liasas / Serina C-Palmitoiltransferasa Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article