CRISPR/Cas9-mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV-positive hepatocellular carcinoma cells.

Song, Jia; Zhang, Xiaochao; Ge, Qianyun; Yuan, Chaoyi; Chu, Liang; Liang, Hui-Fang; Liao, Zhibin; Liu, Qiumeng; Zhang, Zhanguo; Zhang, Bixiang

Song, Jia; Zhang, Xiaochao; Ge, Qianyun; Yuan, Chaoyi; Chu, Liang; Liang, Hui-Fang; Liao, Zhibin; Liu, Qiumeng; Zhang, Zhanguo; Zhang, Bixiang.

Song J; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang X; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, China.
Ge Q; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, China.
Yuan C; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chu L; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, China.
Liang HF; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, China.
Liao Z; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liu Q; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, China.
Zhang Z; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, China.
Zhang B; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

J Cell Biochem ; 119(10): 8419-8431, 2018 11.

Article en En | MEDLINE | ID: mdl-29904948

Asunto(s)

Sistemas CRISPR-Cas; Carcinogénesis/metabolismo; Carcinoma Hepatocelular/patología; Antígenos de Superficie de la Hepatitis B/metabolismo; Virus de la Hepatitis B/metabolismo; Neoplasias Hepáticas/patología; Animales; Carcinoma Hepatocelular/etiología; Proliferación Celular; Técnicas de Inactivación de Genes/métodos; Células HEK293; Células Hep G2; Antígenos de Superficie de la Hepatitis B/análisis; Antígenos de Superficie de la Hepatitis B/genética; Hepatitis B Crónica/complicaciones; Humanos; Interleucina-6/análisis; Interleucina-6/metabolismo; Neoplasias Hepáticas/etiología; Ratones Desnudos; Transfección; Carga Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CRISPR/Cas9; HBV; HBsAg; HCC; IL-6; tumorigenicity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Carcinoma Hepatocelular / Carcinogénesis / Sistemas CRISPR-Cas / Antígenos de Superficie de la Hepatitis B / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article

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