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Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
Pu, Szu-Yuan; Wouters, Randy; Schor, Stanford; Rozenski, Jef; Barouch-Bentov, Rina; Prugar, Laura I; O'Brien, Cecilia M; Brannan, Jennifer M; Dye, John M; Herdewijn, Piet; De Jonghe, Steven; Einav, Shirit.
  • Pu SY; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology , Stanford University School of Medicine , Stanford , California 94305 , United States.
  • Wouters R; Medicinal Chemistry, Rega Institute for Medical Research , KU Leuven , Herestraat 49, Bus 1041 , 3000 Leuven , Belgium.
  • Schor S; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology , Stanford University School of Medicine , Stanford , California 94305 , United States.
  • Rozenski J; Medicinal Chemistry, Rega Institute for Medical Research , KU Leuven , Herestraat 49, Bus 1041 , 3000 Leuven , Belgium.
  • Barouch-Bentov R; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology , Stanford University School of Medicine , Stanford , California 94305 , United States.
  • Prugar LI; U.S. Army Medical Research Institute of Infectious Diseases , Viral Immunology Branch , Fort Detrick , Maryland 21702 , United States.
  • O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases , Viral Immunology Branch , Fort Detrick , Maryland 21702 , United States.
  • Brannan JM; U.S. Army Medical Research Institute of Infectious Diseases , Viral Immunology Branch , Fort Detrick , Maryland 21702 , United States.
  • Dye JM; U.S. Army Medical Research Institute of Infectious Diseases , Viral Immunology Branch , Fort Detrick , Maryland 21702 , United States.
  • Herdewijn P; Medicinal Chemistry, Rega Institute for Medical Research , KU Leuven , Herestraat 49, Bus 1041 , 3000 Leuven , Belgium.
  • De Jonghe S; Medicinal Chemistry, Rega Institute for Medical Research , KU Leuven , Herestraat 49, Bus 1041 , 3000 Leuven , Belgium.
  • Einav S; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology , Stanford University School of Medicine , Stanford , California 94305 , United States.
J Med Chem ; 61(14): 6178-6192, 2018 Jul 26.
Article en En | MEDLINE | ID: mdl-29953812
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Tiazoles / Proteínas Serina-Treonina Quinasas / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridinas / Tiazoles / Proteínas Serina-Treonina Quinasas / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article