Economic burden of resected (stage IB-IIIA) non-small cell lung cancer in France, Germany and the United Kingdom: A retrospective observational study (LuCaBIS).
Lung Cancer
; 124: 298-309, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-29961557
ABSTRACT
OBJECTIVES:
New adjuvant treatments are being developed for patients with resected non-small cell lung cancer (NSCLC). Due to scarcity of real-world data available for treatment costs and resource utilization, health technology and cost-effectiveness assessments can be limited. We estimated the burden and cost-of-illness associated with completely resected stage IB-IIIA NSCLC in France, Germany and the United Kingdom (UK). MATERIALS ANDMETHODS:
Eligible patients were aged ≥18 years with completely resected stage IB-IIIA NSCLC between August 2009 and July 2012. Patients (living or deceased) were enrolled at clinical sites by a systematic sampling method. Data were obtained from medical records and patient surveys. Direct, indirect and patient out-of-pocket expenses were estimated by multiplying resource use by country-specific unit costs. National annual costs were estimated based on disease prevalence data available from published sources.RESULTS:
39 centers provided data from 831 patients of whom patient surveys were evaluable in 306 patients. Median follow-up was 26 months. The mean total direct costs per patient during follow-up were 19,057 (France), 14,185 (Germany), and 8377 (UK). The largest cost drivers were associated with therapies received (12,375 France; 3694 UK), and hospitalization/emergency costs (7706 Germany). Monthly direct costs per patient were the highest during the distant metastasis/terminal illness phase in France (15,562) and Germany (6047) and during the adjuvant treatment period in the UK (2790). Estimated mean total indirect costs per patient were 696 (France), 2476 (Germany), and 1414 (UK). Estimates for the annual national direct cost were 478.4 million (France), 574.6 million (Germany) and 325.8 million (UK).CONCLUSION:
To our knowledge, this is the first comprehensive study describing the burden of illness for patients with completely resected stage IB-IIIA NSCLC. The economic burden was substantial in all three countries. Treatment of NSCLC is associated with large annual national costs, mainly incurred during disease progression.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Costo de Enfermedad
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Carcinoma de Pulmón de Células no Pequeñas
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Neoplasias Pulmonares
Tipo de estudio:
Health_economic_evaluation
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2018
Tipo del documento:
Article