Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis.
Eur J Immunol
; 48(10): 1632-1643, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-30028501
ABSTRACT
The role of mitochondrial biogenesis during naïve to effector differentiation of CD8+ T cells remains ill explored. In this study, we describe a critical role for early mitochondrial biogenesis in supporting cytokine production of nascent activated human naïve CD8+ T cells. Specifically, we found that prior to the first round of cell division activated naïve CD8+ T cells rapidly increase mitochondrial mass, mitochondrial respiration, and mitochondrial reactive oxygen species (mROS) generation, which were all inter-linked and important for CD8+ T cell effector maturation. Inhibition of early mitochondrial biogenesis diminished mROS dependent IL-2 production - as well as subsequent IL-2 dependent TNF, IFN-γ, perforin, and granzyme B production. Together, these findings point to the importance of mitochondrial biogenesis during early effector maturation of CD8+ T cells.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Biogénesis de Organelos
/
Diferenciación Celular
/
Linfocitos T CD8-positivos
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Mitocondrias
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article