IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria.
J Exp Med
; 215(8): 2019-2034, 2018 08 06.
Article
en En
| MEDLINE
| ID: mdl-30042191
ABSTRACT
Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF). In both mice and humans, MAFF is detected predominantly in mucus-resident bacteria, and its expression requires the presence of complex microbiota. Expression of the MAFF system facilitates symbiosis with other members of the phylum Firmicutes and promotes protection from a chemically induced model of colitis. Our data reveal a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Simbiosis
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Bacterias
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Inmunoglobulina A
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Microbioma Gastrointestinal
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2018
Tipo del documento:
Article