A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both <i>Status Epilepticus</i> and Optic Nerve Crush Animal Models.

Vinet, Jonathan; Costa, Anna-Maria; Salinas-Navarro, Manuel; Leo, Giuseppina; Moons, Lieve; Arckens, Lutgarde; Biagini, Giuseppe

A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in Both Status Epilepticus and Optic Nerve Crush Animal Models.

Vinet, Jonathan; Costa, Anna-Maria; Salinas-Navarro, Manuel; Leo, Giuseppina; Moons, Lieve; Arckens, Lutgarde; Biagini, Giuseppe.

Vinet J; Laboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. jonathan.vinet@unimore.it.
Costa AM; Laboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. annamaria.costa@unimore.it.
Salinas-Navarro M; Laboratory of Neural Circuit Development and Regeneration, Department of Biology, KU Leuven, 3000 Leuven, Belgium. manuel.salinas@um.es.
Leo G; Laboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. giuseppina.leo@unimore.it.
Moons L; Laboratory of Neural Circuit Development and Regeneration, Department of Biology, KU Leuven, 3000 Leuven, Belgium. lieve.moons@kuleuven.be.
Arckens L; Laboratory of Neuroplasticity and Neuroproteomics, Department of Biology, KU Leuven, 3000 Leuven, Belgium. lut.arckens@kuleuven.be.
Biagini G; Laboratory of Experimental Epileptology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. giuseppe.biagini@unimore.it.

Int J Mol Sci ; 19(8)2018 Jul 25.

Article en En | MEDLINE | ID: mdl-30044455

Asunto(s)

Inhibidores Enzimáticos/farmacología; Metaloproteinasa 12 de la Matriz/metabolismo; Fármacos Neuroprotectores/farmacología; Traumatismos del Nervio Óptico/tratamiento farmacológico; Pironas/química; Estado Epiléptico/metabolismo; Animales; Región CA3 Hipocampal/efectos de los fármacos; Región CA3 Hipocampal/patología; Giro Dentado/efectos de los fármacos; Giro Dentado/patología; Modelos Animales de Enfermedad; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/uso terapéutico; Humanos; Masculino; Ratones Endogámicos C57BL; Compresión Nerviosa/efectos adversos; Fármacos Neuroprotectores/química; Fármacos Neuroprotectores/uso terapéutico; Nervio Óptico/efectos de los fármacos; Nervio Óptico/patología; Pilocarpina/farmacología; Ratas; Convulsiones; Estado Epiléptico/inducido químicamente

Palabras clave

bloodbrain barrier leakage; metalloproteinase-12; optical neuropathy; pilocarpine; retinal ganglion cells; status epilepticus

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pironas / Estado Epiléptico / Fármacos Neuroprotectores / Traumatismos del Nervio Óptico / Inhibidores Enzimáticos / Metaloproteinasa 12 de la Matriz Límite: Animals / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

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