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Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity.
Fukuda, Miwa; Sasaki, Tomomi; Hashimoto, Tomoko; Miyachi, Hiroyuki; Waki, Minoru; Asai, Akira; Takikawa, Osamu; Ohno, Osamu; Matsuno, Kenji.
  • Fukuda M; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
  • Sasaki T; Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan.
  • Hashimoto T; Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan.
  • Miyachi H; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
  • Waki M; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
  • Asai A; Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
  • Takikawa O; National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan.
  • Ohno O; Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan.
  • Matsuno K; Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano-machi, Hachi-oji, Tokyo 192-0015, Japan. Electronic address: matz@cc.kogakuin.ac.jp.
Bioorg Med Chem Lett ; 28(17): 2846-2849, 2018 09 15.
Article en En | MEDLINE | ID: mdl-30055888
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiourea / Indolamina-Pirrol 2,3,-Dioxigenasa / Quinurenina Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiourea / Indolamina-Pirrol 2,3,-Dioxigenasa / Quinurenina Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article