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Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.
Pircs, Karolina; Petri, Rebecca; Madsen, Sofia; Brattås, Per Ludvik; Vuono, Romina; Ottosson, Daniella R; St-Amour, Isabelle; Hersbach, Bob A; Matusiak-Brückner, Monika; Lundh, Sofia Hult; Petersén, Åsa; Déglon, Nicole; Hébert, Sébastien S; Parmar, Malin; Barker, Roger A; Jakobsson, Johan.
  • Pircs K; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Petri R; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Madsen S; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Brattås PL; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Vuono R; John van Geest Centre for Brain Repair and Department of Neurology, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK.
  • Ottosson DR; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • St-Amour I; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, CHUL, Québec, QC G1V 4G2, Canada.
  • Hersbach BA; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Matusiak-Brückner M; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Lundh SH; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC D11, Lund University, 221 84 Lund, Sweden.
  • Petersén Å; Translational Neuroendocrine Research Unit (TNU), Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC D11, Lund University, 221 84 Lund, Sweden.
  • Déglon N; Laboratory of Cellular and Molecular Neurotherapies (LCMN), Department of Clinical Neuroscience (DNC), Neuroscience Research Center (CRN), Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
  • Hébert SS; Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, CHUL, Québec, QC G1V 4G2, Canada.
  • Parmar M; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden.
  • Barker RA; John van Geest Centre for Brain Repair and Department of Neurology, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK; Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem
  • Jakobsson J; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, 221 84 Lund, Sweden. Electronic address: johan.jakobsson@med.lu.se.
Cell Rep ; 24(6): 1397-1406, 2018 08 07.
Article en En | MEDLINE | ID: mdl-30089251
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Enfermedad de Huntington / MicroARNs / Proteínas Argonautas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Enfermedad de Huntington / MicroARNs / Proteínas Argonautas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article