TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining.

Kawale, Ajinkya S; Akopiants, Konstantin; Valerie, Kristoffer; Ruis, Brian; Hendrickson, Eric A; Huang, Shar-Yin N; Pommier, Yves; Povirk, Lawrence F

Kawale, Ajinkya S; Akopiants, Konstantin; Valerie, Kristoffer; Ruis, Brian; Hendrickson, Eric A; Huang, Shar-Yin N; Pommier, Yves; Povirk, Lawrence F.

Kawale AS; Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Akopiants K; Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Valerie K; Department of Radiation Oncology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Ruis B; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Hendrickson EA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Huang SN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5068, Bethesda, MD 20892-4255, USA.
Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5068, Bethesda, MD 20892-4255, USA.
Povirk LF; Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

Nucleic Acids Res ; 46(17): 8926-8939, 2018 09 28.

Article en En | MEDLINE | ID: mdl-30113698

Asunto(s)

Reparación del ADN por Unión de Extremidades; ADN/genética; Endonucleasas/genética; Epistasis Genética; Proteínas Nucleares/genética; Hidrolasas Diéster Fosfóricas/genética; Supervivencia Celular/efectos de los fármacos; Citotoxinas/farmacología; ADN/química; ADN/metabolismo; Roturas del ADN de Doble Cadena; Proteínas de Unión al ADN; Endonucleasas/antagonistas & inhibidores; Endonucleasas/deficiencia; Células HCT116; Células HEK293; Humanos; Proteínas Nucleares/antagonistas & inhibidores; Proteínas Nucleares/deficiencia; Inhibidores de la Síntesis del Ácido Nucleico/farmacología; Hidrolasas Diéster Fosfóricas/deficiencia; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Proteína 1 de Unión al Supresor Tumoral P53/genética; Proteína 1 de Unión al Supresor Tumoral P53/metabolismo; Cinostatina/farmacología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN / Proteínas Nucleares / Hidrolasas Diéster Fosfóricas / Endonucleasas / Epistasis Genética / Reparación del ADN por Unión de Extremidades Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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