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Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
Madi, Ayman; Fisher, David; Maughan, Timothy S; Colley, James P; Meade, Angela M; Maynard, Julie; Humphreys, Vikki; Wasan, Harpreet; Adams, Richard A; Idziaszczyk, Shelley; Harris, Rebecca; Kaplan, Richard S; Cheadle, Jeremy P.
  • Madi A; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Fisher D; MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.
  • Maughan TS; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Colley JP; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Meade AM; MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.
  • Maynard J; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Humphreys V; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Wasan H; Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.
  • Adams RA; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Idziaszczyk S; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Harris R; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
  • Kaplan RS; MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.
  • Cheadle JP; Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. Electronic address: cheadlejp@cardiff.ac.uk.
Eur J Cancer ; 102: 31-39, 2018 Oct.
Article en En | MEDLINE | ID: mdl-30114658
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Dihidrouracilo Deshidrogenasa (NADP) / Capecitabina / Fluorouracilo / Pruebas de Farmacogenómica / Variantes Farmacogenómicas / Oxaliplatino Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Protocolos de Quimioterapia Combinada Antineoplásica / Dihidrouracilo Deshidrogenasa (NADP) / Capecitabina / Fluorouracilo / Pruebas de Farmacogenómica / Variantes Farmacogenómicas / Oxaliplatino Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article