Quantitative analysis of the dose-response of white spot syndrome virus in shrimp.
J Fish Dis
; 41(11): 1733-1744, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-30117593
ABSTRACT
White spot syndrome virus (WSSV) is an important cause of mortality and economic losses in shrimp farming. Although WSSV-induced mortality is virus dose dependent and WSSV infection does not necessarily lead to mortality, the relationships between virus-particle dose, infection and mortality have not been analysed quantitatively. Here, we explored WSSV dose-response by a combination of experiments, modelling and meta-analysis. We performed dose-response experiments in Penaeus vannamei postlarvae, recorded host mortality and detected WSSV infection. When we fitted infection models to these data, two models-differing in whether they incorporated heterogeneous host susceptibility to the virus or not-were supported for two independent experiments. To determine the generality of these results, we reanalysed published data sets and then performed a meta-analysis. We found that WSSV dose-response kinetics is indeed variable over experiments. We could not clearly identify which specific infection model has the most support by meta-analysis, but we argue that these results also are most concordant with a model incorporating varying levels of heterogeneous host susceptibility to WSSV. We have identified suitable models for analysing WSSV dose-response, which can elucidate the most basic virus-host interactions and help to avoid underestimating WSSV infection at low virus doses.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
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Carga Viral
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Penaeidae
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Virus del Síndrome de la Mancha Blanca 1
Tipo de estudio:
Prognostic_studies
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Systematic_reviews
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article