i-Motif DNA: structural features and significance to cell biology.
Nucleic Acids Res
; 46(16): 8038-8056, 2018 09 19.
Article
en En
| MEDLINE
| ID: mdl-30124962
ABSTRACT
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine base pairs (CC+). First observed 25 years ago, and considered by many as a mere structural oddity, interest in and discussion on the biological role of i-motifs have grown dramatically in recent years. In this review we focus on structural aspects of i-motif formation, the factors leading to its stabilization and recent studies describing the possible role of i-motifs in fundamental biological processes.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
Citosina
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Conformación de Ácido Nucleico
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article