Fast Morphological Gallbladder Changes Triggered by a Hypercholesterolemic Diet.
Ann Hepatol
; 17(5): 857-863, 2018 Aug 24.
Article
en En
| MEDLINE
| ID: mdl-30145572
ABSTRACT
INTRODUCTION AND AIM:
Obesity is a worldwide epidemic problem, described as a risk factor for hepatic diseases, such as non-alcoholic fatty liver disease and other pathologies related to development of cholesterol crystals and cholesterol gallbladder stones. It has been reported that cholesterol overload may cause hepatic damage; however, little is known about the effects of an acute hypercholesterolemic diet on the gallbladder. The aim of this manuscript was to evaluate the impact of a cholesterol-rich diet on the gallbladder. MATERIAL ANDMETHODS:
The study included ten eight-week-old C57BL6 male mice, which were divided into two study groups and fed different diets for 48 h a hypercholesterolemic diet and a balanced Chow diet. After 48 h, the mice were analyzed by US with a Siemens Acuson Antares equipment. Mice were subsequently sacrificed to carry out a cholesterol analysis with a Refloton System (Roche), a crystal analysis with a Carl Zeiss microscope with polarized light, and a histological analysis with Hematoxylin-eosin staining.RESULTS:
The hypercholesterolemic diet induced an increase in gallbladder size and total cholesterol content in the bile, along with important histological changes.CONCLUSION:
Cholesterol overloads not only trigger hepatic damage, but also affect the gallbladder significantly.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Colesterol en la Dieta
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Cálculos Biliares
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Ultrasonografía
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Vesícula Biliar
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Hipercolesterolemia
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article