A biochemical and genetic discovery pipeline identifies PLCÎ´4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz, Marcin; Broselid, Stefan; DiGiacomo, Vincent; Park, Jong-Chan; Luebbers, Alex; Garcia-Navarrete, Lucia; Blanco-Canosa, Juan B; Baillie, George S; Garcia-Marcos, Mikel

Maziarz, Marcin; Broselid, Stefan; DiGiacomo, Vincent; Park, Jong-Chan; Luebbers, Alex; Garcia-Navarrete, Lucia; Blanco-Canosa, Juan B; Baillie, George S; Garcia-Marcos, Mikel.

Maziarz M; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
Broselid S; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
DiGiacomo V; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
Park JC; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
Luebbers A; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
Garcia-Navarrete L; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118.
Blanco-Canosa JB; the Department of Biological Chemistry and Molecular Modelling, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain, and.
Baillie GS; the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.
Garcia-Marcos M; From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, 02118 mgm1@bu.edu.

J Biol Chem ; 293(44): 16964-16983, 2018 11 02.

Article en En | MEDLINE | ID: mdl-30194280

Asunto(s)

Proteínas de Unión al GTP Heterotriméricas/metabolismo; Fosfolipasa C delta/química; Fosfolipasa C delta/genética; Secuencias de Aminoácidos; Cristalografía por Rayos X; Subunidades alfa de la Proteína de Unión al GTP/química; Subunidades alfa de la Proteína de Unión al GTP/genética; Subunidades alfa de la Proteína de Unión al GTP/metabolismo; Factores de Intercambio de Guanina Nucleótido/química; Factores de Intercambio de Guanina Nucleótido/genética; Factores de Intercambio de Guanina Nucleótido/metabolismo; Proteínas de Unión al GTP Heterotriméricas/química; Proteínas de Unión al GTP Heterotriméricas/genética; Humanos; Fosfolipasa C delta/metabolismo; Unión Proteica; Receptores Acoplados a Proteínas G/química; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Proteínas Represoras/química; Proteínas Represoras/genética; Proteínas Represoras/metabolismo; Transducción de Señal

Palabras clave

G-proteincoupled receptor (GPCR); GTPase; bioluminescence resonance energy transfer (BRET); guanine nucleotide exchange factor (GEF); heterotrimeric G-protein; phospholipase C

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP Heterotriméricas / Fosfolipasa C delta Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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