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Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism.
Benej, Martin; Hong, Xiangqian; Vibhute, Sandip; Scott, Sabina; Wu, Jinghai; Graves, Edward; Le, Quynh-Thu; Koong, Albert C; Giaccia, Amato J; Yu, Bing; Chen, Ching-Shih; Papandreou, Ioanna; Denko, Nicholas C.
  • Benej M; Department of Radiation Oncology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210.
  • Hong X; Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210.
  • Vibhute S; Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53233.
  • Scott S; Department of Medicinal Chemistry School of Pharmacy, Ohio State University, Columbus, OH 43210.
  • Wu J; Department of Radiation Oncology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210.
  • Graves E; Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210.
  • Le QT; Department of Radiation Oncology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210.
  • Koong AC; Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210.
  • Giaccia AJ; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.
  • Yu B; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.
  • Chen CS; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX 77030.
  • Papandreou I; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305.
  • Denko NC; Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53233.
Proc Natl Acad Sci U S A ; 115(42): 10756-10761, 2018 10 16.
Article en En | MEDLINE | ID: mdl-30201710
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Papaverina / Fármacos Sensibilizantes a Radiaciones / Hipoxia de la Célula / Neoplasias Pulmonares / Mitocondrias / NADH Deshidrogenasa Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Papaverina / Fármacos Sensibilizantes a Radiaciones / Hipoxia de la Célula / Neoplasias Pulmonares / Mitocondrias / NADH Deshidrogenasa Límite: Animals / Female / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article