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Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
Shibata, Norihito; Shimokawa, Kenichiro; Nagai, Katsunori; Ohoka, Nobumichi; Hattori, Takayuki; Miyamoto, Naoki; Ujikawa, Osamu; Sameshima, Tomoya; Nara, Hiroshi; Cho, Nobuo; Naito, Mikihiko.
  • Shibata N; Divisions of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.
  • Shimokawa K; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
  • Nagai K; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
  • Ohoka N; Axcelead Drug Discovery Partners, Inc., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-0012, Japan.
  • Hattori T; Divisions of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.
  • Miyamoto N; Divisions of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-9501, Japan.
  • Ujikawa O; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
  • Sameshima T; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
  • Nara H; Axcelead Drug Discovery Partners, Inc., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-0012, Japan.
  • Cho N; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
  • Naito M; Pharmaceutical Research Division, Takeda Pharmaceutical Co. Ltd., 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan.
Sci Rep ; 8(1): 13549, 2018 09 10.
Article en En | MEDLINE | ID: mdl-30202081
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Ubiquitina-Proteína Ligasas / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Ubiquitina-Proteína Ligasas / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article