The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.

Hagenbeek, Thijs J; Webster, Joshua D; Kljavin, Noelyn M; Chang, Matthew T; Pham, Trang; Lee, Ho-June; Klijn, Christiaan; Cai, Allen G; Totpal, Klara; Ravishankar, Buvana; Yang, Naiying; Lee, Da-Hye; Walsh, Kevin B; Hatzivassiliou, Georgia; de la Cruz, Cecile C; Gould, Stephen E; Wu, Xiumin; Lee, Wyne P; Yang, Shuqun; Zhang, Zhixiang; Gu, Qingyang; Ji, Qunsheng; Jackson, Erica L; Lim, Dae-Sik; Dey, Anwesha

Hagenbeek, Thijs J; Webster, Joshua D; Kljavin, Noelyn M; Chang, Matthew T; Pham, Trang; Lee, Ho-June; Klijn, Christiaan; Cai, Allen G; Totpal, Klara; Ravishankar, Buvana; Yang, Naiying; Lee, Da-Hye; Walsh, Kevin B; Hatzivassiliou, Georgia; de la Cruz, Cecile C; Gould, Stephen E; Wu, Xiumin; Lee, Wyne P; Yang, Shuqun; Zhang, Zhixiang; Gu, Qingyang; Ji, Qunsheng; Jackson, Erica L; Lim, Dae-Sik; Dey, Anwesha.

Hagenbeek TJ; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Webster JD; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
Kljavin NM; Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Chang MT; Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Pham T; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Lee HJ; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Klijn C; Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.
Cai AG; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Totpal K; Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Ravishankar B; Department of Cancer Immunotherapy, Genentech Inc., South San Francisco, CA 94080, USA.
Yang N; Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Lee DH; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Walsh KB; Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Hatzivassiliou G; Department of Cancer Immunotherapy, Genentech Inc., South San Francisco, CA 94080, USA.
de la Cruz CC; Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Gould SE; Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Wu X; Department of Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
Lee WP; Department of Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
Yang S; Oncology Business Unit, Research Service Division, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Zhang Z; Oncology Business Unit, Research Service Division, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Gu Q; Oncology Business Unit, Research Service Division, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Ji Q; Oncology Business Unit, Research Service Division, WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Jackson EL; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Lim DS; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Dey A; Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. dey.anwesha@gene.com.

Sci Signal ; 11(547)2018 09 11.

Article en En | MEDLINE | ID: mdl-30206136

Asunto(s)

Proteínas de Unión al ADN/genética; Inflamación/genética; Péptidos y Proteínas de Señalización Intracelular/genética; Neoplasias Hepáticas/genética; Hígado/metabolismo; Proteínas Nucleares/genética; Proteínas Serina-Treonina Quinasas/genética; Factores de Transcripción/genética; Animales; Proteínas de Ciclo Celular; Citocinas/genética; Citocinas/metabolismo; Proteínas de Unión al ADN/metabolismo; Perfilación de la Expresión Génica/métodos; Vía de Señalización Hippo; Humanos; Inflamación/metabolismo; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Hígado/patología; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patología; Ratones Endogámicos C57BL; Mutación; Proteínas Nucleares/metabolismo; Proteínas Serina-Treonina Quinasas/metabolismo; Transducción de Señal/genética; Factores de Transcripción de Dominio TEA; Transactivadores; Factores de Transcripción/metabolismo; Proteínas Coactivadoras Transcripcionales con Motivo de Unión a PDZ; Trasplante Heterólogo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Proteínas Serina-Treonina Quinasas / Péptidos y Proteínas de Señalización Intracelular / Proteínas de Unión al ADN / Inflamación / Hígado / Neoplasias Hepáticas Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article

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