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Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma.
Purzner, Teresa; Purzner, James; Buckstaff, Taylor; Cozza, Giorgio; Gholamin, Sharareh; Rusert, Jessica M; Hartl, Tom A; Sanders, John; Conley, Nicholas; Ge, Xuecai; Langan, Marc; Ramaswamy, Vijay; Ellis, Lauren; Litzenburger, Ulrike; Bolin, Sara; Theruvath, Johanna; Nitta, Ryan; Qi, Lin; Li, Xiao-Nan; Li, Gordon; Taylor, Michael D; Wechsler-Reya, Robert J; Pinna, Lorenzo A; Cho, Yoon-Jae; Fuller, Margaret T; Elias, Joshua E; Scott, Matthew P.
  • Purzner T; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. mscott@stanford.edu tpurzner@stanford.edu.
  • Purzner J; Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S1A1, Canada.
  • Buckstaff T; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cozza G; Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S1A1, Canada.
  • Gholamin S; Department of Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Rusert JM; Department of Molecular Medicine, University of Padua, Padova, PD 35122, Italy.
  • Hartl TA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sanders J; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Conley N; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ge X; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Langan M; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ramaswamy V; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ellis L; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA.
  • Bolin S; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Theruvath J; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Nitta R; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Qi L; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
  • Li XN; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Li G; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Taylor MD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wechsler-Reya RJ; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Pinna LA; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Cho YJ; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Fuller MT; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Elias JE; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Scott MP; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Sci Signal ; 11(547)2018 09 11.
Article en En | MEDLINE | ID: mdl-30206138
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Transducción de Señal / Neoplasias Cerebelosas / Proteómica / Quinasa de la Caseína II / Proteínas Hedgehog / Meduloblastoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Transducción de Señal / Neoplasias Cerebelosas / Proteómica / Quinasa de la Caseína II / Proteínas Hedgehog / Meduloblastoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article