A Copper10-Paclitaxel crystal; a medicinally active drug delivery platform.
Bioorg Med Chem Lett
; 28(20): 3409-3417, 2018 11 01.
Article
en En
| MEDLINE
| ID: mdl-30219524
ABSTRACT
Paclitaxel is a well-known cancer drug that functions as a mitotic inhibitor. This work focuses on a copper based crystal that encapsulates the pharmaceutical agent and serves as a drug delivery agent. A Copper10-Pacitaxil1 chloride (CU10PAC1) complex is synthesized and tested against the National Cancer Institute's sixty cell line panel. The 101 ratio results in a crystal that was examined by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spec (MALDI-TOF-MS), Scanning Electron Microscopy (SEM) and Proton (1H) and Carbon (13C) Nuclear Magnetic Resonance (NMR). The potential attributes of a copper based crystal as an in vivo drug carrier for Paclitaxel are discussed.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Paclitaxel
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Cobre
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article