Xylopsides A-D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana.
Org Biomol Chem
; 16(37): 8408-8412, 2018 09 26.
Article
en En
| MEDLINE
| ID: mdl-30221279
ABSTRACT
Four unprecedented guaiane dimers, xylopsides A-D (1-4), were isolated and identified from the roots of Xylopia vielana. The structures of 1-4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1-4 showed two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 µM in RAW264.7 cells stimulated by LPS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dimerización
/
Sesquiterpenos de Guayano
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Xylopia
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article