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Oncological Outcomes of Nipple-Sparing Mastectomy: A Single-Center Experience of 1989 Patients.
Galimberti, Viviana; Morigi, Consuelo; Bagnardi, Vincenzo; Corso, Giovanni; Vicini, Elisa; Fontana, Sabrina Kahler Ribeiro; Naninato, Paola; Ratini, Silvia; Magnoni, Francesca; Toesca, Antonio; Kouloura, Andriana; Rietjens, Mario; De Lorenzi, Francesca; Vingiani, Andrea; Veronesi, Paolo.
  • Galimberti V; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy. viviana.galimberti@ieo.it.
  • Morigi C; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Bagnardi V; Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy.
  • Corso G; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Vicini E; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Fontana SKR; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Naninato P; Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  • Ratini S; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Magnoni F; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Toesca A; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Kouloura A; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • Rietjens M; Division of Senology, IRCCS European Institute of Oncology, Milan, Italy.
  • De Lorenzi F; Division of Plastic and Reconstructive Surgery, IRCCS European Institute of Oncology, Milan, Italy.
  • Vingiani A; Division of Plastic and Reconstructive Surgery, IRCCS European Institute of Oncology, Milan, Italy.
  • Veronesi P; Department of Pathology, IRCCS European Institute of Oncology, Milan, Italy.
Ann Surg Oncol ; 25(13): 3849-3857, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30225833
BACKGROUND: Nipple-sparing mastectomy (NSM) is increasingly used in women with breast cancer who are not eligible for conservative surgery, but extensive outcome data are lacking and indications have not been established. OBJECTIVE: The aim of this study was to assess the oncological outcomes of NSM in a large series of patients with invasive or in situ breast cancer treated at a single center. METHODS: We analyzed 1989 consecutive women who had an NSM in 2003-2011, for invasive (1711 patients) or in situ cancer (278 patients) at the European Institute of Oncology, Italy, and followed-up to December 2016. Endpoints were local recurrences, recurrences in the nipple-areola complex (NAC), NAC necrosis, and overall survival (OS). RESULTS: After a median follow-up of 94 months (interquartile range 70-117), 91/1711 (5.3%) patients with invasive cancer had local recurrence (4.8% invasive disease, 0.5% in situ disease), and 11/278 (4.0%) patients with in situ disease had local recurrence (1.8% invasive disease, 2.2% in situ disease). Thirty-six (1.8%) patients had NAC recurrence, 9 with in situ disease (4 invasive and 5 in situ recurrences), and 27 with invasive disease (18 invasive and 9 in situ recurrences). NAC loss for necrosis occurred in 66 (3.3%) patients. There were 131 (6.6%) deaths, 109 (5.5%) as a result of breast cancer. OS at 5 years was 96.1% in women with invasive cancer and 99.2% in women with in situ disease. CONCLUSIONS: The findings in this large series, with a median follow-up of nearly 8 years, indicate that NSM is oncologically safe for selected patients. The rate of NAC loss was acceptably low.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular / Carcinoma Ductal de Mama / Carcinoma Intraductal no Infiltrante / Mastectomía / Recurrencia Local de Neoplasia / Pezones Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Humans / Middle aged Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular / Carcinoma Ductal de Mama / Carcinoma Intraductal no Infiltrante / Mastectomía / Recurrencia Local de Neoplasia / Pezones Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Humans / Middle aged Idioma: En Año: 2018 Tipo del documento: Article