Resistance to ß-lactams in enterococci.
Rev Argent Microbiol
; 51(2): 179-183, 2019.
Article
en En
| MEDLINE
| ID: mdl-30243525
ABSTRACT
Enterococci are intrinsically resistant to several antimicrobial classes and show a great ability to acquire new mechanisms of resistance. Resistance to ß-lactam antibiotics is a major concern because these drugs either alone or in combination are commonly used for the treatment of enterococcal infections. Ampicillin resistance, which is rare in Enterococcus faecalis, occurs in most of the hospital-associated Enterococcus faecium isolates. High-level resistance to ampicillin in E. faecium is mainly due to the enhanced production of PBP5 and/or by polymorphisms in the beta subunit of this protein. The dissemination of high-level ampicillin resistance can be the result of both clonal spread of strains with mutated pbp5 genes and horizontal gene transfer.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enterococcus
/
Beta-Lactamas
Límite:
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article