Impact of diabetes on clinical outcomes after revascularization with sirolimus-eluting and biolimus-eluting stents with biodegradable polymer from the SORT OUT VII trial.
Catheter Cardiovasc Interv
; 93(4): 567-573, 2019 03 01.
Article
en En
| MEDLINE
| ID: mdl-30244533
ABSTRACT
OBJECTIVES:
In this substudy of the SORT OUT VII trial, the clinical outcomes among patient with diabetes mellitus treated with Orsiro sirolimus-eluting stent (O-SES; Biotronik, Bülach, Switzerland) or Nobori biolimus-eluting stent (N-BES; Terumo, Tokyo, Japan) were compared.BACKGROUND:
Diabetes is associated with increased risk of target lesion failure (TLF) after percutaneous coronary intervention.METHODS:
In total, 2525 patients were randomized to stent implantation with O-SES (n = 1261, diabetes n = 236) or N-BES (n = 1264, diabetes n = 235). The primary endpoint, TLF, was a composite of cardiac death, target-lesion myocardial infarction (MI), or target lesion revascularization (TLR) within 2 years.RESULTS:
At 2 year, TLF did not differ between O-SES vs N-BES in diabetic (9.3% vs 9.4%; RR 0.98, 95% CI 0.54-1.78) patients. The individual components of the primary endpoint did not differ among stent type. In diabetics, cardiac death occurred in 3% of O-SES-treated and in 3.8% of N-BES-treated patients (RR 0.77, 95% CI 0.29-2.08), MI occurred in 3.0% of O-SES-treated and in 3.8% of N-BES-treated patients (RR 0.76, 95% CI 0.28-2.06) and TLR occurred in 5,5% of O-SES-treated and in 6.0% of N-BES-treated patients (RR 0.91, 95% CI 0.43-1.95).CONCLUSION:
TLF did not differ between O-SES- and N-BES-treated diabetic patients.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
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Enfermedad de la Arteria Coronaria
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Fármacos Cardiovasculares
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Sirolimus
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Implantes Absorbibles
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Diabetes Mellitus
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Síndrome Coronario Agudo
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Stents Liberadores de Fármacos
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Intervención Coronaria Percutánea
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2019
Tipo del documento:
Article