Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies.
Molecules
; 23(10)2018 Sep 21.
Article
en En
| MEDLINE
| ID: mdl-30248936
ABSTRACT
4-Chloro-3-nitrophenylthioureas 1â»30 were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2â»64 µg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds 1â»6 and 8â»19 were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC50 ≤ 10 µM). The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Feniltiourea
/
Queratinocitos
/
Antibacterianos
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article