Renal Injury during Long-Term Crizotinib Therapy.
Int J Mol Sci
; 19(10)2018 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-30257437
ABSTRACT
Crizotinib is highly effective against anaplastic lymphoma kinase-positive and c-ros oncogen1-positive non-small cell lung cancer. Renal dysfunction is associated with crizotinib therapy but the mechanism is unknown. Here, we report a case of anaplastic lymphoma kinase positive non-small cell lung cancer showing multiple cysts and dysfunction of the kidneys during crizotinib administration. We also present results demonstrating that long-term crizotinib treatment induces fibrosis and dysfunction of the kidneys by activating the tumor necrosis factor-α/nuclear factor-κB signaling pathway. In conclusion, this study shows the renal detrimental effects of crizotinib, suggesting the need of careful monitoring of renal function during crizotinib therapy.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
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Enfermedades Renales Quísticas
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Crizotinib
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Riñón
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Neoplasias Pulmonares
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Antineoplásicos
Límite:
Aged
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Animals
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Female
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Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article