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Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism.
Bozza, Silvia; Käsermann, Fabian; Kaveri, Srini V; Romani, Luigina; Bayry, Jagadeesh.
  • Bozza S; Department of Medicine, University of Perugia, Perugia, Italy.
  • Käsermann F; Research, CSL Behring AG, Bern, Switzerland.
  • Kaveri SV; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe-Immunopathologie et immuno-intervention thérapeutique, Sorbonne Université, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Romani L; Department of Experimental Medicine, University of Perugia, Perugia, Italy.
  • Bayry J; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe-Immunopathologie et immuno-intervention thérapeutique, Sorbonne Université, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Eur J Immunol ; 49(1): 195-198, 2019 01.
Article en En | MEDLINE | ID: mdl-30267564
ABSTRACT
Intravenous immunoglobuin (IVIG) exerts protective effects in experimental allergic bronchopulmonary aspergillosis (ABPA) via a sialylation-dependent mechanism. The protection was associated with reduced recruitment of eosinophils, diminished goblet cell hyperplasia, suppressed Th2 and Th17 responses and reciprocally enhanced regulatory T cells and IL-10, and decreased IgE levels in the circulation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aspergilosis Broncopulmonar Alérgica / Inmunoglobulinas Intravenosas / Linfocitos T Reguladores / Células Th2 / Células Caliciformes / Eosinófilos / Células Th17 Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aspergilosis Broncopulmonar Alérgica / Inmunoglobulinas Intravenosas / Linfocitos T Reguladores / Células Th2 / Células Caliciformes / Eosinófilos / Células Th17 Límite: Animals / Humans Idioma: En Año: 2019 Tipo del documento: Article