Effect of left atrial to left femoral artery bypass and renin-angiotensin system blockade on renal blood flow and function during and after thoracic aortic occlusion.
J Vasc Surg
; 5(2): 329-35, 1987 Feb.
Article
en En
| MEDLINE
| ID: mdl-3029438
ABSTRACT
Temporary thoracic aortic occlusion can result in renal insufficiency with or without adjuncts to avoid distal hypoperfusion. In a canine model of thoracic aortic occlusion, left atrial to left femoral bypass was compared with blockade of the renin-angiotensin system. Renin-angiotensin system blockade with the converting enzyme inhibitor, MK422, resulted in restoration of baseline renal blood flow and glomerular filtration 30 minutes after cross-clamp release. Left atrial to left femoral bypass resulted in significant reduction in both renal blood flow and glomerular filtration 30 minutes after cross-clamp release. Stimulation of the renin-angiotensin system plays a significant role in the altered renal hemodynamics and glomerular filtration rates after thoracic aortic occlusion.
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Banco de datos:
MEDLINE
Asunto principal:
Aorta Torácica
/
Perfusión
/
Circulación Renal
/
Sistema Renina-Angiotensina
/
Inhibidores de la Enzima Convertidora de Angiotensina
/
Enalapril
Límite:
Animals
Idioma:
En
Año:
1987
Tipo del documento:
Article