Homologies between small nuclear RNAs and LAV/HTLV-III sequences and their possible role in the cytopathic effect of the virus.
Med Hypotheses
; 22(1): 27-33, 1987 Jan.
Article
en En
| MEDLINE
| ID: mdl-3031434
ABSTRACT
The mechanism of action of LAV/HTLV-III resulting in a pronounced cytopathic effect is still unknown. We demonstrate that the long terminal repeat (LTR) sequence and env gene of LAV/HTLV-III contain regions of 70-80% homology and/or complementarity with regions of small nuclear (sn) RNAs U1 and U2. On this basis, we hypothesize that the cytotoxic effect of LAV/HTLV-III is due - at least partly - to the inhibition of processing of cellular hnRNAs by competing for splice junction sites and/or by complexing with U1 and especially U2 RNAs.
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Banco de datos:
MEDLINE
Asunto principal:
ARN Viral
/
Secuencia de Bases
/
Homología de Secuencia de Ácido Nucleico
/
ARN Nuclear Pequeño
/
VIH
Idioma:
En
Año:
1987
Tipo del documento:
Article