A Novel Donkey Milk-derived Human Milk Fortifier in Feeding Preterm Infants: A Randomized Controlled Trial.
J Pediatr Gastroenterol Nutr
; 68(1): 116-123, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30320665
ABSTRACT
OBJECTIVES:
The purpose of the present randomized controlled clinical trial was to compare the use of donkey milk-derived fortifier (DF) with commercial bovine milk-derived fortifier (BF) in very preterm or very-low-birth-weight newborns, in terms of feeding tolerance.METHODS:
This trial included 156 newborns born at <32 weeks of gestational age and/or with a birth weight ≤1500âg. Newborns were randomized 11 to receive enteral feeding with either a BF-arm, or a new, DF-arm for 21 days. The fortification protocol was the same for both study arms, and the 2 diets were designed to be isoproteic and isocaloric. Feeding tolerance was assessed by a standardized protocol.RESULTS:
The risk of feeding intolerance tended to be lower in DF-arm than in BF-arm, with a relative risk reduction of 0.63 (95% confidence interval -0.29, +0.90). The mean number of episodes per newborn of feeding intolerance and feeding interruptions (any duration) were consistently lower in the DF-arm than in the BF-arm. Episodes of bilious gastric residuals and vomiting were significantly lower in the DF-arm. Time needed to reach full enteral feeding (150âmLâ·âkgâ·âday) and daily weight increase between the first day of exclusive enteral feeding (ie, without administering intravenous fluids) and discharge were similar in the BF- and DF-arms.CONCLUSIONS:
These results suggest that DF improve feeding tolerance when compared with standard bovine-derived fortifiers, with a similar auxological outcome.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Recien Nacido Prematuro
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Alimentos Fortificados
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Nutrición Enteral
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Recién Nacido de muy Bajo Peso
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Leche
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Leche Humana
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Guideline
Límite:
Animals
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Female
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Humans
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Male
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Newborn
Idioma:
En
Año:
2019
Tipo del documento:
Article