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Neural activity in the social decision-making network of the brown anole during reproductive and agonistic encounters.
Kabelik, David; Weitekamp, Chelsea A; Choudhury, Shelley C; Hartline, Jacob T; Smith, Alexandra N; Hofmann, Hans A.
  • Kabelik D; Department of Biology, Rhodes College, Memphis, TN 38112, USA; Program in Neuroscience, Rhodes College, Memphis, TN 38112, USA. Electronic address: kabelikd@rhodes.edu.
  • Weitekamp CA; Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA.
  • Choudhury SC; Department of Biology, Rhodes College, Memphis, TN 38112, USA; Program in Neuroscience, Rhodes College, Memphis, TN 38112, USA.
  • Hartline JT; Department of Biology, Rhodes College, Memphis, TN 38112, USA; Program in Neuroscience, Rhodes College, Memphis, TN 38112, USA.
  • Smith AN; Department of Biology, Rhodes College, Memphis, TN 38112, USA; Program in Neuroscience, Rhodes College, Memphis, TN 38112, USA.
  • Hofmann HA; Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: hans@utex
Horm Behav ; 106: 178-188, 2018 11.
Article en En | MEDLINE | ID: mdl-30342012
ABSTRACT
Animals have evolved flexible strategies that allow them to evaluate and respond to their social environment by integrating the salience of external stimuli with internal physiological cues into adaptive behavioral responses. A highly conserved social decision-making network (SDMN), consisting of interconnected social behavior and mesolimbic reward networks, has been proposed to underlie such adaptive behaviors across all vertebrates, although our understanding of this system in reptiles is very limited. Here we measure neural activation across the SDMN and associated regions in the male brown anole (Anolis sagrei), within both reproductive and agonistic contexts, by quantifying the expression density of the immediate early gene product Fos. We then relate this neural activity measure to social context, behavioral expression, and activation (as measured by colocalization with Fos) of different phenotypes of 'source' node neurons that produce neurotransmitters and neuropeptides known to modulate SDMN 'target' node activity. Our results demonstrate that measures of neural activation across the SDMN network are generally independent of specific behavioral output, although Fos induction in a few select nodes of the social behavior network component of the SDMN does vary with social environment and behavioral output. Under control conditions, the mesolimbic reward nodes of the SDMN actually correlate little with the social behavior nodes, but the interconnectivity of these SDMN components increases dramatically within a reproductive context. When relating behavioral output to specific source node activation profiles, we found that catecholaminergic activation is associated with the frequency and intensity of reproductive behavior output, as well as with aggression intensity. Finally, in terms of the effects of source node activation on SDMN activity, we found that Ile8-oxytocin (mesotocin) populations correlate positively, while Ile3-vasopressin (vasotocin), catecholamine, and serotonin populations correlate negatively with SDMN activity. Taken together, our findings present evidence for a highly dynamic SDMN in reptiles that is responsive to salient cues in a social context-dependent manner.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Sexual Animal / Conducta Social / Toma de Decisiones / Agresión / Lagartos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Sexual Animal / Conducta Social / Toma de Decisiones / Agresión / Lagartos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2018 Tipo del documento: Article