Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood.
Liver Int
; 39(6): 1147-1154, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30347485
ABSTRACT
BACKGROUND & AIMS:
We aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non-alcoholic fatty liver disease.METHODS:
Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I normal body mass index, no metabolic disturbances; II normal body mass index, one or more metabolic disturbances; III overweight/obese, no metabolic disturbances; IV overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Group 1 normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non-alcoholic fatty liver disease.RESULTS:
The risk for adult non-alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non-alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non-obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight-fold to 10-fold increased risk (P < 0.001).CONCLUSIONS:
Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non-alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Índice de Masa Corporal
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Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
País como asunto:
Europa
Idioma:
En
Año:
2019
Tipo del documento:
Article