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A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids.
Nadai, Matteo; Doria, Filippo; Scalabrin, Matteo; Pirota, Valentina; Grande, Vincenzo; Bergamaschi, Greta; Amendola, Valeria; Winnerdy, Fernaldo Richtia; Phan, Anh Tuân; Richter, Sara N; Freccero, Mauro.
  • Nadai M; Department of Molecular Medicine , University of Padua , via Gabelli 63 , 35121 Padua , Italy.
  • Doria F; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
  • Scalabrin M; Department of Molecular Medicine , University of Padua , via Gabelli 63 , 35121 Padua , Italy.
  • Pirota V; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
  • Grande V; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
  • Bergamaschi G; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
  • Amendola V; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
  • Winnerdy FR; School of Physical and Mathematical Sciences , Nanyang Technological University , Singapore 637371 , Singapore.
  • Phan AT; School of Physical and Mathematical Sciences , Nanyang Technological University , Singapore 637371 , Singapore.
  • Richter SN; Department of Molecular Medicine , University of Padua , via Gabelli 63 , 35121 Padua , Italy.
  • Freccero M; Department of Chemistry , University of Pavia , V. le Taramelli 10 , 27100 Pavia , Italy.
J Am Chem Soc ; 140(44): 14528-14532, 2018 11 07.
Article en En | MEDLINE | ID: mdl-30351011
ABSTRACT
A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry experiments highlight a unique and unexpected selectivity in cleaving G-quadruplex sequences. This selectivity relies both on the binding affinity and structural features of the targeted G-quadruplexes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Organometálicos / ADN / Cobre / G-Cuádruplex / Imidas / Naftalenos Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Organometálicos / ADN / Cobre / G-Cuádruplex / Imidas / Naftalenos Idioma: En Año: 2018 Tipo del documento: Article