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Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists.
Riddy, Darren M; Cook, Anna E; Shackleford, David M; Pierce, Tracie L; Mocaer, Elisabeth; Mannoury la Cour, Clotilde; Sors, Aurore; Charman, William N; Summers, Roger J; Sexton, Patrick M; Christopoulos, Arthur; Langmead, Christopher J.
  • Riddy DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Cook AE; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Shackleford DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Pierce TL; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Mocaer E; Institut de Recherches Internationales Servier, 50 Rue Carnot, 92284, Suresnes, France.
  • Mannoury la Cour C; Institut de Recherches Internationales Servier, 50 Rue Carnot, 92284, Suresnes, France.
  • Sors A; Institut de Recherches Internationales Servier, 50 Rue Carnot, 92284, Suresnes, France.
  • Charman WN; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Summers RJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Langmead CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: chris.langmead@monash.edu.
Neuropharmacology ; 144: 244-255, 2019 01.
Article en En | MEDLINE | ID: mdl-30359639
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores sigma / Receptores Histamínicos H3 / Antagonistas de los Receptores Histamínicos H3 Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores sigma / Receptores Histamínicos H3 / Antagonistas de los Receptores Histamínicos H3 Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article