Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site.

Nassar, Omneya M; Li, Changhong; Stanley, Charles A; Pettitt, B Montgomery; Smith, Thomas J

Nassar, Omneya M; Li, Changhong; Stanley, Charles A; Pettitt, B Montgomery; Smith, Thomas J.

Nassar OM; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas.
Li C; Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Stanley CA; Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pettitt BM; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas.
Smith TJ; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas.

Proteins ; 87(1): 41-50, 2019 01.

Article en En | MEDLINE | ID: mdl-30367518

Asunto(s)

Glutamato Deshidrogenasa/química; Guanosina Trifosfato/metabolismo; Hiperinsulinismo/genética; Hipoglucemia/genética; Proteínas Mutantes/química; Mutación; Regulación Alostérica; Glutamato Deshidrogenasa/genética; Glutamato Deshidrogenasa/metabolismo; Humanos; Hiperinsulinismo/enzimología; Hipoglucemia/enzimología; Modelos Moleculares; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Conformación Proteica

Palabras clave

allostery; binding free energy; glutamate dehydrogenase; insulin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Mutantes / Glutamato Deshidrogenasa / Guanosina Trifosfato / Hiperinsulinismo / Hipoglucemia / Mutación Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

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