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YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.
Rivera-Reyes, Adrian; Ye, Shuai; E Marino, Gloria; Egolf, Shaun; E Ciotti, Gabrielle; Chor, Susan; Liu, Ying; Posimo, Jessica M; Park, Paul M C; Pak, Koreana; Babichev, Yael; Sostre-Colón, Jaimarie; Tameire, Feven; Leli, Nektaria Maria; Koumenis, Constantinos; C Brady, Donita; Mancuso, Anthony; Weber, Kristy; Gladdy, Rebecca; Qi, Jun; Eisinger-Mathason, T S Karin.
  • Rivera-Reyes A; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Ye S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • E Marino G; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Egolf S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • E Ciotti G; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Chor S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Liu Y; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Posimo JM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Park PMC; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Pak K; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.
  • Babichev Y; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Sostre-Colón J; Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Tameire F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
  • Leli NM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Koumenis C; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • C Brady D; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Mancuso A; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Weber K; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Gladdy R; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Qi J; Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Eisinger-Mathason TSK; Department of Orthopedic Surgery, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Cell Death Dis ; 9(11): 1108, 2018 10 31.
Article en En | MEDLINE | ID: mdl-30382078
Asunto(s)
Proteínas Adaptadoras Transductoras de Señales/genética; Autofagia/genética; Proteínas de Ciclo Celular/genética; Regulación Neoplásica de la Expresión Génica; Neoplasias de los Músculos/genética; FN-kappa B/genética; Sarcoma/genética; Factor de Transcripción Activador 6/genética; Factor de Transcripción Activador 6/metabolismo; Proteínas Adaptadoras Transductoras de Señales/metabolismo; Animales; Autofagia/efectos de los fármacos; Azepinas/farmacología; Proteínas CLOCK/genética; Proteínas CLOCK/metabolismo; Proteínas de Ciclo Celular/metabolismo; Diferenciación Celular; Línea Celular; Transformación Celular Neoplásica/genética; Transformación Celular Neoplásica/metabolismo; Transformación Celular Neoplásica/patología; Relojes Circadianos/efectos de los fármacos; Relojes Circadianos/genética; Humanos; Ratones; Ratones Transgénicos; Neoplasias de los Músculos/tratamiento farmacológico; Neoplasias de los Músculos/metabolismo; Neoplasias de los Músculos/patología; Músculo Esquelético/efectos de los fármacos; Músculo Esquelético/metabolismo; Músculo Esquelético/patología; Mioblastos/efectos de los fármacos; Mioblastos/metabolismo; Mioblastos/patología; FN-kappa B/metabolismo; Sarcoma/tratamiento farmacológico; Sarcoma/metabolismo; Sarcoma/patología; Transducción de Señal; Células Madre/efectos de los fármacos; Células Madre/metabolismo; Células Madre/patología; Triazoles/farmacología; Respuesta de Proteína Desplegada/efectos de los fármacos; Vorinostat/farmacología; Proteínas Señalizadoras YAP; eIF-2 Quinasa/genética; eIF-2 Quinasa/metabolismo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sarcoma / Autofagia / Regulación Neoplásica de la Expresión Génica / FN-kappa B / Proteínas de Ciclo Celular / Neoplasias de los Músculos / Proteínas Adaptadoras Transductoras de Señales Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sarcoma / Autofagia / Regulación Neoplásica de la Expresión Génica / FN-kappa B / Proteínas de Ciclo Celular / Neoplasias de los Músculos / Proteínas Adaptadoras Transductoras de Señales Tipo de estudio: Prognostic_studies Idioma: En Año: 2018 Tipo del documento: Article