Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer.
Sci Rep
; 8(1): 16234, 2018 11 02.
Article
en En
| MEDLINE
| ID: mdl-30390003
ABSTRACT
Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model. KU treatment downregulated the epithelial-mesenchymal markers Twist, Snail, and Slug and the metastasis-related genes CAPN1, CDC42, CFL1, IGF1, WASF1, and WASL in cells and tumor tissues. The present results suggest the potential application of the water-soluble form of UA, KU, in anticancer therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Neoplasias Colorrectales
/
Regulación Neoplásica de la Expresión Génica
/
Ácido Selénico
/
Antineoplásicos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
2018
Tipo del documento:
Article