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Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial.
de Melo Soares, Mariana Sales; D'Almeida Borges, Cristine; de Mendonça Invernici, Marcos; Frantz, Fabiani Gai; de Figueiredo, Luciene Cristina; de Souza, Sérgio Luis Scombatti; Taba, Mario; Messora, Michel Reis; Novaes, Arthur Belém.
  • de Melo Soares MS; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • D'Almeida Borges C; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • de Mendonça Invernici M; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • Frantz FG; Departament of Clinical, Toxicological and Bromatological Analyzes, School of Pharmaceutical Sciences School of Ribeirao Preto, University of Sao Paulo - USP, Ribeirao Preto, SP, Brazil.
  • de Figueiredo LC; Department of Periodontology Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
  • de Souza SLS; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • Taba M; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • Messora MR; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil.
  • Novaes AB; Departament of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, FORP-USP, Ribeirao Preto, SP, 14040-904, Brazil. novaesjr@forp.usp.br.
Clin Oral Investig ; 23(8): 3173-3182, 2019 Aug.
Article en En | MEDLINE | ID: mdl-30392080
ABSTRACT

OBJECTIVES:

This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis. MATERIALS AND

METHODS:

Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Root Planing (SRP) or SRP. aPDT was performed by using a laser light source with 660 nm wavelength associated with a photosensitizer. The applications were performed in four episodes (at days 0, 2, 7, and 14). All patients were monitored for 90 days. Plaque index, probing depth, clinical attachment level, and bleeding on probing were performed at baseline, 30, and 90 days after the SRP. Gingival crevicular fluid and subgingival plaque samples were collected for immunological and microbiological analysis, respectively. Data obtained were statistically analyzed.

RESULTS:

aPDT as an adjunct to SRP did not demonstrate statistically significant advantages on clinical parameters when compared with SRP alone. No statistic significant differences between groups were observed (p < 0.05). Levels of anti-inflammatory cytokines and bacterial species were comparable in both groups at day 90 after treatment.

CONCLUSION:

Periodontal treatment with SRP + aPDT in multiples episodes was not able to promote additional clinical, immunological, and microbiological benefits in smokers when compared SRP alone in patients with chronic periodontitis. CLINICAL RELEVANCE Multiple episodes of aPDT adjunctive to non-surgical treatment did not improve significantly the clinical, immunological, and microbiological parameters when compared with SRP alone. More randomized clinical trials are needed to evaluate adjuvant therapies for scaling and root planning in smokers with chronic periodontitis. ClinicalTrials.gov Identifier NCT03039244.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica / Fumadores / Antiinfecciosos Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica / Fumadores / Antiinfecciosos Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Año: 2019 Tipo del documento: Article