Impact of Heparin- or Nonheparin-Coated Circuits on Platelet Function in Pediatric Cardiac Surgery.
Ann Thorac Surg
; 107(4): 1241-1247, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30395857
ABSTRACT
BACKGROUND:
Extracorporeal circuit coating has been shown to improve coagulation derangements during pediatric cardiopulmonary bypass (CPB). This study compared platelet function and hemostasis activation in pediatric cardiac surgery conducted with nonheparin coating (Balance; Medtronic, Minneapolis, MN) versus heparin-based coating (Carmeda; Medtronic) circuits.METHODS:
A prospective, randomized, double-center trial was conducted in children older than 1 month undergoing congenital heart disease treatment. Blood samples were collected at baseline (T0), 15 minutes after the start of CPB (T1), and 15 minutes (T2) and 1 hour after the conclusion of CPB (T3). The primary end point of the study was to detect potential differences in ß-thromboglobulin levels between the two groups at T2. Other coagulation and platelet function indicators were analyzed as secondary end points.RESULTS:
The concentration of ß-thromboglobulin increased significantly at T2 in both groups. However, there was no significant difference between the groups across all time points. There was no difference in the secondary end points between the groups.CONCLUSIONS:
The two circuits showed similar biological effects on platelet function and coagulation. This observation may be useful in optimizing the conduct of CPB and in rationalizing its cost for the treatment of congenital heart disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Coagulación Sanguínea
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Heparina
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Puente Cardiopulmonar
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Activación Plaquetaria
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Circulación Extracorporea
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Cardiopatías Congénitas
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
Límite:
Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Año:
2019
Tipo del documento:
Article