Osteoblast autophagy in glucocorticoid-induced osteoporosis.
J Cell Physiol
; 234(4): 3207-3215, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30417506
ABSTRACT
Administration of glucocorticoids is an effective strategy for treating many inflammatory and autoimmune diseases. However, glucocorticoid treatment can have adverse effects on bone, leading to glucocorticoid-induced osteoporosis (GIO), the most common form of secondary osteoporosis. Although the pathogenesis of GIO has been studied for decades, over the past ten years the autophagy machinery has been implicated as a novel mechanism. Autophagy in osteoblasts, osteocytes, and osteoclasts plays a critical role in the maintenance of bone homeostasis. Herein, we specifically discuss how osteoblast autophagy responds to glucocorticoids and its role in the development of GIO.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Osteoporosis
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Autofagia
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Glucocorticoides
Límite:
Animals
/
Humans
Idioma:
En
Año:
2019
Tipo del documento:
Article