Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma.

Corbetta, Cristina; Di Ianni, Natalia; Bruzzone, Maria Grazia; Patanè, Monica; Pollo, Bianca; Cantini, Gabriele; Cominelli, Manuela; Zucca, Ileana; Pisati, Federica; Poliani, Pietro Luigi; Finocchiaro, Gaetano; Pellegatta, Serena

Corbetta, Cristina; Di Ianni, Natalia; Bruzzone, Maria Grazia; Patanè, Monica; Pollo, Bianca; Cantini, Gabriele; Cominelli, Manuela; Zucca, Ileana; Pisati, Federica; Poliani, Pietro Luigi; Finocchiaro, Gaetano; Pellegatta, Serena.

Corbetta C; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Di Ianni N; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Bruzzone MG; Experimental Imaging and Neuro-Radiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Patanè M; Unit of Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Pollo B; Unit of Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Cantini G; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Cominelli M; Unit of Pathology, University of Brescia, Brescia, Italy.
Zucca I; Experimental Imaging and Neuro-Radiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Pisati F; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Poliani PL; Unit of Pathology, University of Brescia, Brescia, Italy.
Finocchiaro G; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Pellegatta S; Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Int J Cancer ; 144(10): 2539-2554, 2019 05 15.

Article en En | MEDLINE | ID: mdl-30418668

Asunto(s)

Sistema de Transporte de Aminoácidos X-AG/metabolismo; Transportador 1 de Aminoácidos Excitadores/metabolismo; Glioblastoma/metabolismo; Animales; Apoptosis/efectos de los fármacos; Apoptosis/fisiología; Ácido Aspártico/metabolismo; Astrocitos/efectos de los fármacos; Astrocitos/metabolismo; Benzopiranos/farmacología; Línea Celular Tumoral; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Femenino; Glioma/metabolismo; Ácido Glutámico/metabolismo; Humanos; Ratones; Ratones Endogámicos C57BL; Transporte de Proteínas/efectos de los fármacos; Transporte de Proteínas/fisiología; ATPasa Intercambiadora de Sodio-Potasio/metabolismo

Palabras clave

GLAST/EAAT1; STAT3; UCPH-101; glioblastoma; glutamate

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glioblastoma / Sistema de Transporte de Aminoácidos X-AG / Transportador 1 de Aminoácidos Excitadores Límite: Animals / Female / Humans Idioma: En Año: 2019 Tipo del documento: Article

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