Trends in Q fever serologic testing by immunofluorescence from four large reference laboratories in the United States, 2012-2016.
Sci Rep
; 8(1): 16670, 2018 11 12.
Article
en En
| MEDLINE
| ID: mdl-30420599
ABSTRACT
Laboratory testing for Q fever (Coxiella burnetii) is essential for a differential diagnosis, yet little is known about Q fever diagnostic testing practices in the United States. We retrospectively analyzed Q fever immunoglobulin G (IgG) indirect immunofluorescence assay (IFA) testing data between 1/1/2012-10/31/2016 from ARUP, LabCorp, Mayo Medical Laboratories, and Quest Diagnostics. Data included IgG phase I and phase II titers, patient age and sex, and state and date of specimen collection. On average, 12,821 specimens were tested for Q fever annually by the participating laboratories. Of 64,106 total specimens, 84.1% tested negative for C. burnetii-specific antibodies. Positive titers ranged from 16 to 262,144 against both phase I and phase II antigens. Submission of specimens peaked during the summer months, and more specimens were submitted from the West North Central division. Testing occurred more frequently in males (53%) and increased with age. In conclusion, few U.S. Q fever cases are reported, despite large volumes of diagnostic specimens tested. Review of commercial laboratory data revealed a lack of paired serology samples and patterns of serology titers that differ from case reporting diagnostic criteria.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fiebre Q
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Pruebas Serológicas
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Técnica del Anticuerpo Fluorescente
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
País como asunto:
America do norte
Idioma:
En
Año:
2018
Tipo del documento:
Article