Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.
Cell Host Microbe
; 24(5): 731-742.e6, 2018 11 14.
Article
en En
| MEDLINE
| ID: mdl-30439342
ABSTRACT
Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies influence ZIKV vertical transmission remains unclear. Here, we find that DENV antibodies increase ZIKV infection of placental macrophages (Hofbauer cells [HCs]) from 10% to over 80% and enhance infection of human placental explants. ZIKV-anti-DENV antibody complexes increase viral binding and entry into HCs but also result in blunted type I interferon, pro-inflammatory cytokine, and antiviral responses. Additionally, ZIKV infection of HCs and human placental explants is enhanced in an immunoglobulin G subclass-dependent manner, and targeting FcRn reduces ZIKV replication in human placental explants. Collectively, these findings support a role for pre-existing DENV antibodies in enhancement of ZIKV infection of select placental cell types and indicate that pre-existing immunity to DENV should be considered when addressing ZIKV vertical transmission.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Placenta
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Acrecentamiento Dependiente de Anticuerpo
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Reacciones Cruzadas
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Dengue
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Virus del Dengue
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Infección por el Virus Zika
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Macrófagos
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Anticuerpos Antivirales
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Año:
2018
Tipo del documento:
Article