Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis.
Cancer Manag Res
; 10: 5395-5410, 2018.
Article
en En
| MEDLINE
| ID: mdl-30464635
ABSTRACT
BACKGROUND:
Several epidemiology studies have explored the association between dietary B vitamins' intake and the risk of esophageal cancer (EC). However, the results remain inconclusive. Thus, we conducted a systematic review with meta-analysis to evaluate such association.METHODS:
Literature retrieval was performed using PubMed (Medline), ScienceDirect, and Cochrane Library electronic databases for all studies published from database inception to December 2017.RESULTS:
The meta-analysis included 19 studies and showed an overall decreased risk of EC (OR=0.77, 95% CI 0.68-0.87) in association with multivitamin B (ie, B1, B2, B3, B5, B6, B9, and B12) dietary intake. In a subgroup analysis based on vitamin B subclass, B1, B3, B6, and B9 vitamins were associated with decreased EC risk (vitamin B1 OR=0.68, 95% CI 0.56-0.82; vitamin B3 OR=0.70, 95% CI 0.53-0.94; vitamin B6 OR=0.64, 95% CI 0.49-0.83; and vitamin B9 OR=0.69, 95% CI 0.55-0.86). By contrast, no association was detected between dietary vitamin B2 and vitamin B5 intake and EC risk (vitamin B2 OR=0.86, 95% CI 0.64-1.16; vitamin B5 OR=0.49, 95% CI 0.20-1.20), whereas a potential non-linear dose-response association was found between dietary vitamin B12 intake and EC risk. A statistically significant, inverse association was observed for an increase of 100 µg/day in supplemental vitamin B6 and B9 and EC risk (vitamin B6 OR=0.98, 95% CI 0.98-0.99; vitamin B9 OR= 0.89; 95% CI 0.86-0.94).CONCLUSION:
These findings support that vitamin B may have an influence on carcinogenesis of the esophagus. Vitamin B1, B3, B6, B9 showed a decreased risk of EC, and vitamin B12 showed an increased risk of EC.
Texto completo:
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Banco de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Año:
2018
Tipo del documento:
Article