Single stage epilepsy surgery in children and adolescents with focal cortical dysplasia type II - Prognostic value of the intraoperative electrocorticogram.
Clin Neurophysiol
; 130(1): 20-24, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30472578
ABSTRACT
OBJECTIVE:
To evaluate prospectively the informative/prognostic value of epileptic discharges in the post-resection ECoGs of children with drug-resistant epilepsies and Focal Cortical Dysplasia type II (FCD-II).METHODS:
Included were consecutive patients with focal epilepsies and suspected FCD-II who were planned for single-stage epilepsy surgery based on non-invasive presurgical evaluation results. Intraoperative ECoGs were recorded using a 32-channel system with strip- and/or grid-electrodes. Spikes were defined as transients with a mainly negative component and duration of 20-70â¯ms. Fast activity was defined as rhythmic bursts of polyspikes >13â¯Hz. All ECoGs were analysed visually. The significance of both spikes and fast activity in the post-resection ECoG for seizure outcomes 24â¯months after surgery was evaluated.RESULTS:
Data from 18 patients (five girls) were analysed. 10/18 patients (55.6%) showed spikes in their post-resection ECoGs, five of them showed additional fast activity. 24â¯months after surgery, 12/18 patients (66.7%) were seizure-free. There was a significant correlation between unfavorable seizure outcomes and fast activity in the post-resection ECoGs (pâ¯=â¯0.009), whereas spikes alone were not predictive (pâ¯=â¯0.502).CONCLUSION:
Even when recorded with non-sophisticated techniques, presence of fast activity in post-resection ECoGs might be a valid negative outcome-predictor after surgery in paediatric patients with FCD-II associated drug-resistant epilepsies.SIGNIFICANCE:
Fast activity recorded with a relatively simple ECoG equipment seems also to have prognostic significance and by this might be an alternative to HFOs recorded with highly sophisticated and expensive technologies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Epilepsias Parciales
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Epilepsia
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Malformaciones del Desarrollo Cortical de Grupo I
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Electrocorticografía
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Año:
2019
Tipo del documento:
Article