Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life.
Science
; 241(4874): 1815-7, 1988 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-3051377
ABSTRACT
Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.
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Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Antígenos HLA-A
/
Antígenos HLA-B
/
Trasplante de Riñón
/
Feto
/
Tolerancia Inmunológica
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
1988
Tipo del documento:
Article