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Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat.
Mortuza, Tanzir B; Edwards, Gaylen L; White, Catherine A; Patel, Vandan; Cummings, Brian S; Bruckner, James V.
  • Mortuza TB; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
  • Edwards GL; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
  • White CA; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
  • Patel V; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
  • Cummings BS; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
  • Bruckner JV; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy (T.B.M., C.A.W., B.S.C., J.V.B.), Interdisciplinary Toxicology Program (G.L.E., C.A.W., B.S.C., J.V.B.), and Department of Physiology and Pharmacology, College of Veterinary Medicine (G.L.E.), University of Georgia, Athens, Ge
Drug Metab Dispos ; 47(3): 234-237, 2019 03.
Article en En | MEDLINE | ID: mdl-30523003
ABSTRACT
Permethrin (PER), a type I pyrethroid, is the most widely used insecticide in domestic settings in the United States. The overall objective of this study was to assess the efficiency of the blood-brain barrier (BBB) as an obstacle to the 14C-cis-permethrin (CIS) and 14C-trans-permethrin (TRANS) isomers of PER, and to determine whether its barrier function changes during maturation of the rat. Experiments were conducted to quantify brain uptake of CIS and TRANS in postnatal day 145, 21, and 90 Sprague-Dawley rats. The common carotid artery of anesthetized rats was perfused for 2 or 4 minutes with 1, 10, or 50 µM 14C-CIS or 14C-TRANS in 4% albumin. Brain deposition of each isomer was inversely related to age, with levels in the youngest animals >5 times those in adults. Brain uptake was linear over the 50-fold range of pyrethroid concentrations, indicative of passive, nonsaturable BBB permeation. The extent of uptake of toxicologically relevant concentrations of CIS and TRANS was quite similar. Thus, dissimilar BBB permeation does not contribute to the greater acute neurotoxic potency of CIS, but greater permeability of the immature BBB to CIS and TRANS may contribute to the increased susceptibility of preweanling rodents to the insecticides.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Permetrina / Insecticidas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Permetrina / Insecticidas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2019 Tipo del documento: Article