Effects of antihypertensive agents on circadian blood pressure and heart rate patterns. Review.
Arch Intern Med
; 148(12): 2547-52, 1988 Dec.
Article
en En
| MEDLINE
| ID: mdl-3058070
ABSTRACT
Blood pressure and heart rate exhibit a circadian rhythm, with both rising rapidly during the morning hours and then decreasing throughout the day to a nadir around 3 AM. Current evidence suggests a possible link between cardiovascular events, such as myocardial infarction and sudden cardiac death, which have been shown to occur most frequently during the morning hours, and the rapid rise in blood pressure and heart rate during this same time period. We review data from ambulatory blood pressure studies to ascertain which antihypertensive agents provide the most satisfactory control of blood pressure and heart rate during the hours of 6 AM to 12 noon. Of the forms of drug therapy studied, labetalol, a combined alpha- and beta-blocker, and two calcium channel blockers, nifedipine and verapamil, appear to be the most effective in blunting the rise in arterial blood pressure during these critical morning hours.
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Banco de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Ritmo Circadiano
/
Frecuencia Cardíaca
/
Antihipertensivos
Límite:
Humans
Idioma:
En
Año:
1988
Tipo del documento:
Article